Cardiovascular disease


Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model. Frontiers in Cardiovascular Medicine, 7, Article 601990. Charles, C. J., Li, R. R., Yeung, T., Mazlan, S. M. I., Lai, R. C., de Kleijn, D. P. V., Lim, S. K., & Richards, A. M. (2020).  Link


Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. Regenerative medicine8(2), 197–209.Lai, R. C., Yeo, R. W., Tan, K. H., & Lim, S. K. (2013).   Link

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem cell research10(3), 301–312. Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A., Aguor, E. N., Timmers, L., van Rijen, H. V., Doevendans, P. A., Pasterkamp, G., Lim, S. K., & de Kleijn, D. P. (2013). Link


Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem cell research6(3), 206–214. Timmers, L., Lim, S. K., Hoefer, I. E., Arslan, F., Lai, R. C., van Oorschot, A. A., Goumans, M. J., Strijder, C., Sze, S. K., Choo, A., Piek, J. J., Doevendans, P. A., Pasterkamp, G., & de Kleijn, D. P. (2011).  Link

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regenerative Medicine, 6(4), 481-492. Lai, R. C., Chen, T. S., & Lim, S. K. (2011).  Link


Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem cell research4(3), 214–222. Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., Pasterkamp, G., de Kleijn, D. P., & Lim, S. K. (2010). Link


Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem cell research1(2), 129–137. Timmers, L., Lim, S. K., Arslan, F., Armstrong, J. S., Hoefer, I. E., Doevendans, P. A., Piek, J. J., El Oakley, R. M., Choo, A., Lee, C. N., Pasterkamp, G., & de Kleijn, D. P. (2007).  Link

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